The safety and effectiveness of Asacol for the maintenance of remission of mildly to moderately active ulcerative colitis in pediatric patients have not been established. Efficacy was not demonstrated in a randomized, double-blind 26-week trial of two dosage levels for maintenance of remission of mildly to moderately active ulcerative colitis initiated in 39 patients aged 5 to 17 years. Possible factors contributing to this outcome included the dose range studied and premature termination of the trial. Asacol delayed-release tablets may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Asacol delayed-release tablets with caution. citalopram
Adverse Reactions reported at the 1-week telephone follow-up visit are included. Aseptic necrosis is a condition in which there is death and degeneration of the hip bone. It is a painful condition that can ultimately lead to the need for surgical replacement of the hip. Aseptic necrosis also has been reported in the knee joints. It is not known how corticosteroids cause aseptic necrosis. The estimated incidence of aseptic necrosis among corticosteroid users is low. Patients on corticosteroids who develop pain in the hips or knees should report the pain to their doctors promptly. Early diagnosis of aseptic necrosis with cessation of corticosteroids might decrease the severity of the aseptic necrosis and the need for surgery.
In patients whose symptoms return while corticosteroids are slowly being reduced, the dose of corticosteroids is increased slightly to control the symptoms. Once the symptoms are under control, the reduction of corticosteroids can resume at a slower pace. Unfortunately, many patients who require corticosteroids to induce remissions become corticosteroid dependent, especially individuals who smoke and have disease of the colon. These patients consistently develop symptoms whenever the corticosteroid dose falls below a certain level. In such patients who are corticosteroid dependent as well as in patients who are unresponsive to corticosteroids and other anti-inflammatory medications, immuno-modulator medications, or surgery must be considered. The management of patients who are corticosteroid dependent or patients with severe disease that responds poorly to medications is complex. Doctors who are experienced in treating ulcerative colitis and Crohn's disease and in using immuno-modulators should evaluate these patients.
Keep a food diary to help you figure out which foods cause problems for you and whether or not you're getting enough nutrients. During these procedures, a flexible viewing tube is placed through the into the large intestine. An image of the inside of the intestine is often projected onto a video monitor. A sigmoidoscopy involves examining the lowest part of the large intestine. A colonoscopy can provide a view of all of the large intestine and often the end of the small intestine, which is frequently affected by Crohn's. In either case, the doctor can directly view the to check for signs of ulcers, inflammation, or bleeding.
But other times, the urge to go is unpredictable. Get emergency medical help if you have signs of an allergic reaction to Simponi: hives, itching; nausea; chest pain, difficulty breathing; swelling of your face, lips, tongue, or throat. If you are taking the delayed-release capsule, extended-release capsule, or delayed-release tablet, part of the capsule or tablet may pass into your stool after your body has absorbed the medicine. Contact your doctor if this happens more often than 1 or 2 times. Product Information. Delzicol mesalamine 5-aminosalicylic acid. The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. Safety and efficacy have not been established. Take mesalamine with a full glass of water. Evaluate patients immediately if signs or symptoms of a hypersensitivity reaction are present. Discontinue Asacol HD if an alternative etiology for the signs or symptoms cannot be established. How should I take Uceris? There are many reasons why people have trouble taking their medicine. The presence of other medical problems may affect the use of this medicine. As for adverse events, the researchers reported, most were related to the disease itself -- including worsening symptoms among patients on the lowest drug dose. Akobeng AK, Gardener E 2005. Oral 5-aminosalicylic acid for maintenance of medically-induced remission in Crohn's disease. Cochrane Database of Systematic Reviews 1. Oxford: Update Software. Ask your pharmacist about using those products safely. Mesalamine was negative in the Ames assay for mutagenesis, negative for induction of sister chromatid exchanges SCE and chromosomal aberrations in Chinese hamster ovary cells in vitro, and negative for induction of micronuclei MN in mouse bone marrow polychromatic erythrocytes.
Use with caution. The effects may be increased because of slower removal of the medicine from the body. It may take up to several weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve after 14 weeks of treatment. You will be watched closely for a short time after receiving your dose, to make sure you do not have an allergic reaction to the medication. In children, can slow growth and weaken bones. If it isn't treated, your child can get very sick. RxList is part of the WebMD Health Network. The opinions expressed in the WebMD User Reviews are solely those of the User, who may or may not have medical or scientific training, and do not represent the opinions of WebMD. These member reviews have not been reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other purpose except for compliance with our Terms and Conditions. Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug, and may not reflect the rates observed in practice. Treatment typically begins with aminosalicylates, which are aspirin-like anti-inflammatory drugs such as sulfasalazine Azulfidine Dipentum balsalazide Colazal and Asacol, Lialda, Pentasa, Apriso. Mesalamine can be taken orally or be administered as a rectal suppository or enema to treat ulcerative colitis. Because they are anti-inflammatory, they are effective in both relieving symptoms of a flare-up and maintaining remission. The doctor may also prescribe anti diarrheal agents, antispasmodics, and acid suppressants for symptom relief. When you have an IBD, the symptoms will come and go over a period of many years. That doesn't mean they control you; managing your condition with the help of your health care providers is the best way to stay as healthy as possible in the long term. How should I take Asacol HD mesalamineoral? WebMD User Reviews should not be considered as medical advice and are not a substitute for professional medical advice, diagnosis, or treatment. Never delay or disregard seeking professional medical advice from your physician or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences may be a helpful health information resource but they are never a substitute for professional medical advice from a qualified healthcare provider. caverta
These medicines may relieve symptoms and in the and help go into a period without symptoms. They also may help prevent the disease from becoming active again. Your doctor can do a simple test to find out. For video capsule endoscopy, you swallow a small capsule or pill that holds a miniature video camera. As it travels through the small intestine, it sends images of the lining to a receiver you wear on a belt around your waist. The images are downloaded and reviewed at a computer. The images can provide detailed information about early, mild problems associated with Crohn's disease. This technique may be especially helpful if you have symptoms of Crohn's disease but barium X-rays do not show evidence of the condition. Use: Treatment of mildly to moderately active ulcerative colitis in patients 5 years of age or older tablets or 12 years of age and older capsules. What other drugs will affect mesalamine oral? There is no specific antidote for mesalamine overdose and treatment for suspected acute severe toxicity with Asacol should be symptomatic and supportive. This may include prevention of further gastrointestinal tract absorption, correction of fluid electrolyte imbalance, and maintenance of adequate renal function. Asacol is a pH dependent delayed-release product and this factor should be considered when treating a suspected overdose. For maintenance long-term treatment, 1600 mg per day in divided doses. Included as part of the PRECAUTIONS section. Side effects may go away after you take the medicine for a while. Patients characteristically had a history of previous use of oral 5-ASAs 86% steroids 41% and rectal therapies 49% and demonstrated clinical symptoms of three or more stools over normal per day 87% and obvious blood in the stool most or all of the time 70%. The study population was primarily Caucasian 97% had a mean age of 43 years 8% aged 65 years or older and included slightly more males 56% than females 44%. Using these medicines together may change the amount of medicine that is released in the body. This list is not complete. Other drugs may interact with vedolizumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. And the drug worked quickly. "There was a pretty high remission rate in a short period of time. Each Asacol HD delayed-release tablet for oral administration contains 800 mg of mesalamine, an aminosalicylate. Global Assessment PGA score of 2; the PGA is a four-point scale 0 to 3 that encompasses the clinical assessments of rectal bleeding, stool frequency, and sigmoidoscopy findings. order prescription escitalopram escitalopram
They may be used if other medicines don't control your symptoms. The proportion of patients who achieved success based on the Truncated Mayo Score TM-Mayo based on the stool frequency and rectal bleeding subscales of the Mayo Score and based on the PUCAI was measured after 6 weeks of treatment. Chewable tablets may contain sugar or aspartame. Food and Drug Administration. WebMD does not endorse any specific product, service or treatment. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. The average age of patients in Study 4 was 42 years and 55 % of patients were male. Protect Asacol HD tablets from moisture. Close the container tightly and leave desiccant pouches in the bottle along with the tablets. Nonsteroidal Anti-Inflammatory Drugs NSAIDs may be continued during treatment with this drug. You may receive "killed-virus" vaccines such as a flu shot, polio vaccine, rabies vaccine, or hepatitis A vaccine. Ask your doctor before receiving any vaccine while you are being treated with Entyvio. What Is Crohn's Disease? Another important aspect of self-care is to learn how to manage stress, which may worsen your symptoms. One thing you might want to do is to make a list of things that cause you stress and then consider which ones you can eliminate from your daily routine. Also, when you feel stress coming on, it can help to take several deep breaths and release them slowly by blowing out. Learning to meditate, creating time for yourself, and regular exercise are all important tools for reducing the amount of stress in your life. Ask your health care provider any questions you may have about how to use Asacol delayed-release tablets. Ulceration occurs in the stomach and duodenum in up to one out of every 10 people with Crohn's disease. These strong medicines suppress the to prevent inflammation. Check with your pharmacist about how to dispose of unused medicine. does cvs lipitor
Unless your doctor has OK'd it ahead of time, don't pick and choose your own treatment, Cataldo says. Renal impairment, including minimal change nephropathy, acute and chronic interstitial nephritis, and renal failure, has been reported in patients taking products such as Asacol that contain mesalamine or are converted to mesalamine. Store and dispense in the original bottle, protect from moisture, and keep the bottle tightly closed. Do not remove desiccant pouch silica gel from bottle. Stop using Simponi and call your doctor right away if you have signs of infection such as: fever, chills, muscle aches, feeling very tired, cough, shortness of breath, sweating, skin sores, diarrhea, stomach pain, weight loss, increased urination, or burning when you urinate. Table 1 enumerates adverse reactions that occurred in the three studies. The most common reactions in patients with moderately active ulcerative colitis 602 patients dosed with Asacol HD and 618 patients dosed with mesalamine delayed-release 400 mg were the same as all treated patients. Treatment success was seen in 59 of 98 59% patients using Asacol and 70 of 102 69% patients using sulfasalazine, a non-significant difference. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Simponi only for the indication prescribed. Simponi is sometimes injected into a vein through an IV. A healthcare provider will give you this type of injection once every 4 to 8 weeks. Safety and effectiveness of Asacol HD beyond 6 weeks have not been established. Complete the What is a document? According to Cross, it's possible that with mongersen's mode of action, the drug could avoid the side effects of existing Crohn's drugs -- but that's unproven for now. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication not have serious side effects. N-acetyl-5-aminosalicylic acid are usually about 12 hours, but are variable, ranging from 2 to 15 hours. There is a large inter-subject and intra-subject variability in the plasma concentrations of mesalamine and N-acetyl-5-aminosalicylic acid and in their elimination half-lives following administration of Asacol. how much does ramipril pharmacy ramipril
If the first drugs don't provide the adequate relief, the doctor will likely prescribe a corticosteroid, which is rapid-acting anti-inflammatory agent. Corticosteroids tend to provide rapid relief of symptoms along with a significant decrease in inflammation. However, because of side effects associated with their long-term use, corticosteroids are used only to treat flare-ups and are not used for maintaining remission. The extended-release capsule is specially formulated to release the medicine after it has passed through your stomach into your intestines. Breaking the pill may cause the drug to be released too early in the digestive tract. Maintenance dose: 100 mg subcutaneously every 4 weeks. You don't get enough because you get up often at night to go to the bathroom. If you are taking the delayed-release tablets, swallow them whole. not crush, chew, or break the tablets. Doing so may increase the chance of upset. Absorbed mesalamine is excreted mainly by the kidney as N-acetyl-5-aminosalicylic acid. Unabsorbed mesalamine is excreted in feces. It's found in the grains wheat, barley, rye, and triticale a wheat-rye cross. Do not take other medicines unless they have been discussed with your doctor.
Many other drugs may interact with budesonide, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using. Remember that your doctor has prescribed this because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication not have serious side effects. Eudragit S polyethylene glycol, povidone, sodium starch glycolate, and talc. HD tablet and 732 patients were dosed with the Asacol 400 mg tablet. Follow all directions on the product package, or take as directed by your doctor. For best absorption, if your total daily dose is more than 600 milligrams, then divide your dose and space it throughout the day. The absorbed mesalamine is rapidly acetylated in the gut mucosal wall and by the liver to N-acetyl-5-aminosalicylic acid. If you have ever had tuberculosis or hepatitis B, Simponi can cause these conditions to come back or get worse. You should be tested for these conditions before you start using Simponi. Even if a high-fiber food seems to worsen your UC symptoms during a flare-up, it may not when the flare passes. The only way to know if a particular food is a problem for you is to remove it from your diet and then gradually start to eat it again. If side effects still bother you and you wonder if you should keep taking the medicine, call your doctor. He or she may be able to lower your dose or change your medicine. If your disease is severe, the urge to empty your colon can come on fast and furious. You might be able to predict when it will happen. You might have to go to the bathroom soon after you eat. Certain kinds of foods, like spicy dishes or food with lots of fiber, might make it worse. IBD. It could also be that the body's own tissue causes an autoimmune response. Rectal Suspension Enema is for rectal use only. There are several surgical options available for people with ulcerative colitis. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment. Retreatment is not always associated with repeated hair loss. Clinical studies of Asacol did not include sufficient numbers of patients aged 65 and over to determine whether they respond differently than younger patients. krom.info danocrine
If you are or are planning to become pregnant, talk to your doctor about which medicines might be okay for you to use. Sometimes severe can harm your baby more than the medicines you take to keep it under control. Some medicines, though, should never be taken when you are pregnant. If you think you may have a serious medical problem, seek immediate medical attention. Cerner Multum, Inc. "Australian Product Information. This medication is used with other drugs, rest, and physical therapy in patients who have not responded to other , nonsteroidal anti-inflammatory drugs-. Toxic megacolon, which is an extreme dilation of the colon that is life-threatening; this is associated more with than Crohn's. Follow your doctor's instructions about any restrictions on food, beverages, or activity. Uses: Treatment of mildly to moderately active ulcerative colitis and induction of remission of ulcerative colitis. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Diarrhea and swelling in your colon make it hard for your body to absorb what it needs for energy. The best time to think about nutrition is when you're not having a flare. The Best Diet for Ulcerative Colitis? Study 1 are listed in Table 2 below. Take this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day. Treatment for IBD involves a combination of self-care and medical treatment. order chloroquine payment uk
Swallow the tablets whole and make sure all 4 are taken at the same time as one dose. Do not cut, break, crush, or chew them. Once you've zeroed in on the cause, your doctor can adjust your medicines. You might need a larger dose or a new drug. In published lactation studies, maternal mesalamine doses from various oral and rectal formulations and products ranged from 500 mg to 3 g daily. Friedman S, Lichtenstein GR 2006. Crohn's disease. If you have an IBD, you know it usually runs a waxing and waning course. When there is severe inflammation, the disease is considered active and the person experiences a flare-up of symptoms. When there is less or no inflammation, the person usually is without symptoms and the disease is said to be in remission. What Causes Inflammatory Bowel Disease? Some people using a medicine similar to Entyvio have developed a serious viral infection of the brain that can lead to disability or death. Call your doctor right away if you have any change in your mental state, decreased vision, or problems with speech or walking. These symptoms may start gradually and get worse quickly. It is important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it. Blood or urine tests may be needed to check for unwanted effects. Product Information. Lialda mesalamine 5-aminosalicylic acid. order reductil online
Continued How is it treated? Asacol HD-treated patients in controlled clinical trials. This acute reaction, characterized by cramping, abdominal pain, bloody diarrhea, and occasionally by fever, headache, malaise, pruritus, rash, and conjunctivitis, has been reported after the initiation of Asacol HD tablets as well as other mesalamine products. Symptoms usually abate when Asacol HD tablets are discontinued. It can be easy to forget to take these medicines when you feel good. But doctors say don't miss a dose. That can cause a flare. May cause side effects to become worse. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. The medications can also have side effects. For the current study, Monteleone's team randomly assigned 166 Crohn's patients to one of four groups: three that received different daily doses of mongersen for two weeks; and one that was given inactive pills for comparison. Sulfasalazine blocks the absorption of folic acid. See Drug Reference for a full list of side effects. Drug Reference is not available in all systems. Store in the refrigerator, do not freeze. Protect from light. Keep the medication in its original carton until you are ready to give an injection. Instruct patients to swallow the Asacol tablets whole, taking care not to break, cut, or chew the tablets, because the coating is an important part of the delayed-release formulation. Serious and sometimes fatal infections may occur during treatment with Simponi. The choice of medicine usually depends on how bad the disease is, the part of the affected, and any complications you may have. Asacol against the advice of my doctor. Experts said the findings are encouraging. Our Asacol HD mesalamine Delayed-Release Tablet Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. rosuvastatin
Medicine is one of the many tools your doctor has to treat a health problem. Taking medicine as your doctor suggests will improve your health and may prevent future problems. If you don't take your medicines properly, you may be putting your health and perhaps your life at risk. Put the disease into and keep it from flaring up again. Therefore, when corticosteroids are discontinued, the dose usually is tapered gradually rather than stopped abruptly. Your doctor may prescribe these for a few weeks to control active disease. Uses: Treatment of active mild to moderate distal ulcerative colitis, proctosigmoiditis, or proctitis.
There have been reports of hepatic failure in patients with pre-existing liver disease who have been administered mesalamine. Evaluate the risks and benefits of using Asacol in patients with known liver impairment. Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. Turner D, Otley AR, Mack D, et al. Development, validation, and evaluation of a pediatric ulcerative colitis activity index: A prospective multicenter study. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. If you have an obstruction in the small intestine, the capsule could get stuck and make the obstruction worse. Instruct patients to report to their physician if they experience new or worsening symptoms of cramping, abdominal pain, bloody diarrhea, and sometimes fever, headache, and rash. The average age of patients was 41 years and 49% of patients were male. Adverse reactions leading to withdrawal from Asacol included each in one patient: diarrhea and colitis flare; dizziness, nausea, joint pain, and headache. If concomitant use of Asacol HD and azathioprine or 6-mercaptopurine cannot be avoided, monitor blood tests, including complete blood cell counts and platelet counts. Enemas or that contain medicine. Oral aminosalicylates are used to treat mild to moderate extensive disease pancolitis. where to buy plavix in us
asacol dsc, asacol 60 mg, can you buy asacol in mexico, asacol price in mercury drug philippines, cheap asacol mail order mastercard, asacol cream purchase, cheap asacol purchase mastercard usa, asacol store hours, cheap asacol tablet, purchase now asacol shop otc, asacol price boots, asacol get quit plan, generic asacol money order otc, buy asacol brisbane, asacol retail price, about asacol pills, how to order asacol usa, online asacol rx, asacol buy now online uk, cost of asacol at boots, asacol amazon, discount asacol review, cheapest place asacol, cost of asacol in france, prescription strength asacol dosage, generic asacol versus brand name, generic asacol purchase store, asacol pre, generic asacol indication, brand asacol vs generic, asacol boots pharmacy, asacol how to buy uk, asacol online shop buy now, asacol online shopping zone, cheapest asacol buy australia, asacol uk prices, asacol patch price uk, cost of a asacol dose pack, order generic asacol shop uk, buy asacol online japan, generic asacol uk buy, purchase cheap asacol pharmacy europe, buy generic asacol shopping europe, asacol cost in uk, asacol order store otc, order now cheap asacol uk, buy generic asacol online store, buy asacol delivery, asacol cheap order online payment, purchase now cheap asacol shop, generic asacol order visa, buy asacol mastercard, asacol buy now online usa, asacol order online mastercard australia, cheapest asacol online payment, where to buy infant asacol, cheap asacol do, shop asacol ecuador, cost of asacol at walmart pharmacy, pharmacy asacol basket, asacol suspension, order now cheap asacol europe, order generic asacol pharmacy usa, generic asacol malaysia, order asacol by mail, buy asacol ebay, asacol online fda, asacol as brand name, asacol online price, cost asacol virginia, buy cheapest asacol online australia, asacol online reviews, cheap asacol in mexico, how to buy asacol pills, price asacol remedio, mail order generic asacol visa, cvs pharmacy prices asacol, mail order now asacol australia, price asacol side, what will asacol, cost asacol last, asacol presc, buy asacol in england, asacol price montreal, hot asacol, asacol online mail order now, order cheap asacol online payment, purchase asacol adelaide, purchase asacol with mastercard, store asacol quit, is generic asacol the same, does cvs asacol, order asacol payment uk, where to buy asacol in us, asacol spray price, order asacol online, how much does asacol pharmacy, order prescription asacol
If you are pregnant, your name may be listed on a pregnancy registry. This is to track the outcome of the pregnancy and to evaluate any effects of Entyvio on the baby. To get and stay well, you need to avoid all foods that have gluten. For many people, this means changing everything about the way they eat. This can be challenging. For help, work with a who has experience with gluten-free diets. Together you can find foods you like that don't have gluten. Children receiving corticosteroids experience stunted growth. Biologic therapies are antibodies that target the action of certain other proteins that cause inflammation. Remicade and infliximab-dyyb Inflectra a biosimilar to Remicade, are drugs approved by the FDA to treat moderate to severe Crohn's disease when standard medications have been ineffective. They belong to a class of drugs known as anti-TNF agents. TNF tumor necrosis factor is produced by white blood cells and is believed to be responsible for promoting the tissue damage that occurs with Crohn's disease. Other anti-TNF agents approved for Crohn's disease are adalimumab Humira adalimumab-atto Amjevita a biosimilar to Humira, and certolizumab Cimzia. An alternative to anti-TNF treatment for Crohn's disease are biologics that target integrin, two of which are natalizumab Tysabri and vedolizumab Entyvio. Another drug, ustekinumab Stelara blocks IL-12 and IL-23.
Entyvio is usually given on a schedule that starts the day of your first injection. Your next injections will be given at 2 weeks and 6 weeks after the first injection. Then you will receive an injection every 8 weeks or every 2 months thereafter. Medeva Pharma Suisse AG, licensed to Allergan Pharmaceuticals International Limited. All medicines may cause side effects, but many people have no, or minor, side effects. UC. Besides its nutritional benefits, fiber soaks up excess and can firm stools.
Instruct patients to close the container tightly and to leave any desiccant pouches present in the bottle along with the tablets. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Talk to your doctor about whether these nutrients could be a problem for you. You may need to take vitamins just in case. Nutrition supplement drinks can also make up for missing nutrients, but they may cause diarrhea.
Inform patients that Asacol tablets can be taken with or without food. Some women with Crohn's disease develop fistulas -- abnormal passageways between organs. The concurrent use of mesalamine with azathioprine or 6-mercaptopurine may increase the risk for blood disorders. Do not crush, break, or chew a mesalamine tablet or capsule. Swallow the pill whole. Most adverse effects have been mild and transient.